Pregabalin for the treatment of peripheral neuralgia and adjuvant treatment of localized partial seizures

Pharmacological Effect
Pregabalin has a good therapeutic effect on epilepsy. Studies on various animal epileptic seizure models have shown that pregabalin can significantly prevent epileptic seizures, and its active dose is 3-10 times lower than gabapentin. Studies have found that pregabalin can reduce the sensory and motor spinal cord reflexes of rat pinch-toe stimulation, reduce the related behaviors of neuropathic animal pain models with diabetes, peripheral nerve injury or chemotherapy, and inhibit or reduce the pain-related pain caused by spinal stimuli. the behavior of. Animal studies have found that pregabalin may have advantages in combination with opioids. Pregabalin provides a new option for the clinical treatment of neuropathic pain.

Mechanism
Pregabalin may reduce the calcium-dependent release of some neurotransmitters by modulating calcium channel function. Although pregabalin is a structural derivative of the inhibitory neurotransmitter γ-aminobutyric acid (GABA), it does not directly bind to GABAA, GABAB, or benzodiazepine receptors and does not increase GABAA in cultured neurons Reaction, does not change the concentration of GABA in the brain of rats, and has no acute effect on GABA uptake or degradation. However, the study found that prolonged exposure of cultured neurons to pregabalin increased the density of GABA transporters and the rate of functional GABA transport. Pregabalin does not block sodium channels, has no activity on opioid receptors, does not alter cyclooxygenase activity, has no activity on dopamine and serotonin receptors, and does not inhibit the reactivation of dopamine, serotonin, or norepinephrine. ingest.

Medicine Interactions
1. It is not metabolized by the cytochrome P450 system, therefore, it rarely interacts with other drugs. It does not affect the pharmacokinetics of antiepileptic drugs (such as sodium valproate, phenytoin, lamotrigine, carbazepine, phenobarbital, topiramate), oral contraceptives, oral hypoglycemic agents, diuretics, and insulin.
2. When this product is used together with oxycodone, its recognition function will be reduced and motor function damage will be enhanced.
3. It has an additive effect with lorazepam and ethanol.