Pharma Ingredients

Inclisiran sodium

Inclisiran sodium API (Active Pharmaceutical Ingredient) is studied primarily in the field of RNA interference (RNAi) and cardiovascular therapeutics. As a double-stranded siRNA targeting the PCSK9 gene, it is used in preclinical and clinical research to evaluate long-acting gene-silencing strategies for lowering LDL-C (low-density lipoprotein cholesterol). It also serves as a model compound for investigating siRNA delivery systems, stability, and liver-targeted RNA therapeutics.

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Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH is a dipeptide used as a basic building block in solid-phase peptide synthesis (SPPS). It features two glycine residues and an Fmoc-protected N-terminus, allowing for controlled peptide chain elongation. Due to glycine’s small size and flexibility, this dipeptide is often studied in the context of peptide backbone dynamics, linker design, and structural modeling in peptides and proteins.

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Fmoc-Thr(tBu)-Phe-OH

Fmoc-Thr(tBu)-Phe-OH is a dipeptide building block commonly used in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethyloxycarbonyl) group protects the N-terminus, while the tBu (tert-butyl) group protects the hydroxyl side chain of threonine. This protected dipeptide is studied for its role in facilitating efficient peptide elongation, reducing racemization, and modeling specific sequence motifs in protein structure and interaction studies.

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AEEA-AEEA

AEEA-AEEA is a hydrophilic, flexible spacer commonly used in peptide and drug conjugation research. It consists of two ethylene glycol-based units, making it useful for studying the effects of linker length and flexibility on molecular interactions, solubility, and biological activity. Researchers often use AEEA units to evaluate how spacers influence the performance of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other bioconjugates.

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Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

This compound is a protected, functionalized lysine derivative used in peptide synthesis and drug conjugate development. It features an Fmoc group for N-terminal protection, and a side-chain modification with Eic(OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), and AEEA (aminoethoxyethoxyacetate). These components are designed to study lipidation effects, spacer chemistry, and controlled drug release. It is widely researched in the context of prodrug strategies, ADC linkers, and membrane-interacting peptides.

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Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

This compound is a modified lysine derivative used in peptide synthesis, particularly for constructing targeted or multifunctional peptide conjugates. The Fmoc group allows for stepwise synthesis via Fmoc solid-phase peptide synthesis (SPPS). The side chain is modified with a stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), and two AEEA (aminoethoxyethoxyacetate) linkers, which provide hydrophobicity, charge properties, and flexible spacing. It is commonly studied for its role in drug delivery systems, including antibody-drug conjugates (ADCs) and cell-penetrating peptides.

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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH is a protected tetrapeptide used in peptide synthesis and structural studies. The Boc (tert-butyloxycarbonyl) group protects the N-terminus, while Trt (trityl) groups protect the side chains of histidine and glutamine to prevent unwanted reactions. The presence of Aib (α-aminoisobutyric acid) promotes helical conformations and enhances peptide stability. This peptide is valuable for investigating peptide folding, stability, and as a scaffold for designing biologically active peptides.

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Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH

Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH is a protected tetrapeptide commonly used in peptide synthesis research. The Boc (tert-butyloxycarbonyl) and tBu (tert-butyl) groups serve as protecting groups to prevent side reactions during peptide chain assembly. The inclusion of Aib (α-aminoisobutyric acid) helps to induce helical structures and increase peptide stability. This peptide sequence is studied for its potential in conformational analysis, peptide folding, and as a building block in developing bioactive peptides with enhanced stability and specificity.

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Fmoc-Ile-Aib-OH

Fmoc-Ile-Aib-OH is a dipeptide building block used in solid-phase peptide synthesis (SPPS). It combines Fmoc-protected isoleucine with Aib (α-aminoisobutyric acid), a non-natural amino acid that enhances helix stability and protease resistance.

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Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH is a functionalized amino acid building block designed for targeted drug delivery and bioconjugation. It features an Eic (eicosanoid) moiety for lipid interaction, γ-Glu for targeting, and AEEA spacers for flexibility.

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Boc-Tyr(tBu)-Aib-OH

Boc-Tyr(tBu)-Aib-OH is a protected dipeptide building block used in peptide synthesis, combining Boc-protected tyrosine and Aib (α-aminoisobutyric acid). The Aib residue enhances helix formation and protease resistance.

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Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH

Boc-His(Trt)-Ala-Glu(OtBu)-Gly-OH is a protected tetrapeptide fragment used in solid-phase peptide synthesis (SPPS) and peptide drug development. It includes protective groups for orthogonal synthesis and features a sequence useful in bioactive and structural peptide design.

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