Pegcetacoplan

Pegcetacoplan API

Pegcetacoplan is a pegylated cyclic peptide that acts as a targeted C3 complement inhibitor, developed for the treatment of complement-mediated diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and geographic atrophy (GA) in age-related macular degeneration.

Mechanism & Research:
Pegcetacoplan binds to complement protein C3 and C3b, preventing the activation of the complement cascade. This reduces:
Hemolysis and inflammation in PNH
Retinal cell damage in geographic atrophy
Immune-mediated tissue injury in other complement-driven disorders