Top Suppliers 303-98-0 - Teriparatide Acetate API for Osteoporosis CAS NO.52232-67-4 – Gentolex

Product Detail

Synonyms

PARATHYROIDHORMONEHUMAN: FRAGMENT1-34; PARATHYROIDHORMONE(HUMAN,1-34); PARATHYROIDHORMONE (1-34), HUMAN; PTH (1-34) (HUMAN); PTH(HUMAN,1-34); TERIPARATIDE; Teriparatide acetate. 

Function

Teriparatide can mediate bone metabolism by inhibiting osteoblast apoptosis, activating bone lining cells, and enhancing osteoblast differentiation. Intermittently stimulates the PHT-I receptor on the surface of osteoblasts, bone lining cells and bone marrow stromal stem cells by regulating the adenylate cyclase-cyclic adenosine monophosphate-protein kinase A pathway to promote osteoblast differentiation and prolong osteogenesis cell lifespan; Stimulates the proliferation of osteoblast cell lines through the phosphate C-cytoplasmic calcium-protein Chemicalbook kinase C signaling pathway; By inhibiting the transactivation activity of PPARγ, it reduces the differentiation of stromal cells to adipocyte lineage and increases the number of osteoblasts; Indirectly regulate bone growth by regulating cytokines, for example, iGF-1 can be induced to bind to osteoblasts, thereby promoting bone formation;

The process of bone formation is regulated by the Wnt signaling pathway, thereby increasing bone formation.

FAQ

Can you supply the relevant documentation?

Yes, we can provide most documentation including Certificates of Analysis / Conformance; Insurance; Origin, and other export documents where required.

Quality System

In general, quality system and assurance is in place covering all stage of production of the finished product. Adequate manufacturing and control operations are performed in compliance with the approved procedures/ specifications. Change control and Deviation handling system is in place, and necessary impact assessment and investigation were conducted. Proper procedures are in place to ensure quality of product prior to release into the market.