Reliable Supplier Glutathione Amino Acids - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex
Reliable Supplier Glutathione Amino Acids - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex Detail:
Product Detail
| Name | CARBETOCIN |
| CAS number | 37025-55-1 |
| Molecular formula | C45H69N11O12S |
| Molecular weight | 988.17 |
| EINECS Number | 253-312-6 |
| Specific rotation | D -69.0° (c = 0.25 in 1M acetic acid) |
| Boiling point | 1477.9±65.0 °C (Predicted) |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Storage conditions | -15°C |
| Form | powder |
Synonyms
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Biological activity
Carbetocin, an oxytocin (OT) analog, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has a high affinity (Ki=1.17 μM) for the chimeric N-terminus of the oxytocin receptor. Carbetocin has potential for postpartum hemorrhage research. Carbetocin can penetrate the blood-brain barrier and has antidepressant-like activity by activating oxytocin receptors in the CNS.
Function
Carbetocin is a synthetic long-acting oxytocin 8-peptide analog with agonist properties, and its clinical and pharmacological properties are similar to those of naturally occurring oxytocin. Like oxytocin, carbetocin binds to the hormone receptors of uterine smooth muscle, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tone on the basis of the contractions of the original. Oxytocin receptor levels in the uterus are low in the non-pregnant state, increase during pregnancy, and peak during labor. Therefore, carbetocin has no effect on the non-pregnant uterus, but has a potent uterine contractile effect on the pregnant uterus and the newly produced uterus.
Change Controls
Changes are controlled according to the procedure. Based on the impact and risk and severity, changes are classified as Major, Minor and Site. Site changes have slight impact on safety and quality of product, and therefore do not need approval and notification to the customer; Minor changes have moderate impact on safety and quality of product, and need to notify the customer; Major changes have higher impact on safety and quality of product, and need approval by the customer.
According to the procedure, change control is started with change application in which change details and rational for the change are described. The evaluation is then performed following the application, which is done by change control relevant departments. Meanwhile, the change control is classified into Major level, General level and Minor level. After appropriate evaluation as well as the classification, all level change control should be approved by QA Manager. The change control is executed after approval according to the action plan. The change control is finally closed after QA confirms the change control has been appropriately implemented. If involving client notification, the client should be notified timely after change control approved
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The incredibly abundant projects administration experiences and 1 to one provider model make the superior importance of small business communication and our easy understanding of your expectations for Reliable Supplier Glutathione Amino Acids - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex , The product will supply to all over the world, such as: Zurich, Maldives, Lithuania, Customer's satisfaction is always our quest, creating value for customers is always our duty, a long term mutual-beneficial business relationship is what we are doing for. We are an absolutely reliable partner for yourself in China. Of course, other services, like consulting, can be offered too.
By Merry from Grenada - 2017.02.14 13:19
The factory workers have rich industry knowledge and operational experience, we learned a lot in working with them,we are extremely grateful that we can encount a good company has excellent wokers.
By Tony from Uruguay - 2017.06.22 12:49
