PT-141 10mg
Overview
PT-141 (Bremelanotide) is a synthetic peptide that activates melanocortin receptors (MC3/MC4) in the brain. Unlike PDE-5 inhibitors, it works through the central nervous system rather than blood flow. It is FDA-approved for hypoactive sexual desire disorder (HSDD) in women and is commonly used on an on-demand basis.
Reconstitution Instructions
Vial strength: 10 mg lyophilized powder
1. Draw 3.0 mL of bacteriostatic water.
2. Slowly inject the water down the side of the vial.
3. Gently swirl until fully dissolved (do not shake).
4. Label with name, concentration, and date.
5. Store refrigerated at 2–8 °C (36–46 °F).
Final concentration: 3.33 mg/mL
On-Demand Dosage Protocol
PT-141 is typically used as needed, not daily.
| Purpose | Dose | Volume | U-100 Syringe Units |
|---|---|---|---|
| FDA-recommended dose | 1.75 mg (1750 mcg) | 0.53 mL | ~53 units |
| Moderate starting dose | 1.0 mg (1000 mcg) | 0.30 mL | ~30 units |
| Conservative / first-time dose | 0.5 mg (500 mcg) | 0.15 mL | ~15 units |
Timing:
1. Inject 45–60 minutes before desired effect
2. Maximum: once per day
3. Limit: no more than 8 injections per month
Syringe & Measurement Notes
1. Use U-100 insulin syringes
2. 1 unit = 0.01 mL
3. At 3.33 mg/mL concentration: ≈33.3 mcg per unit
For smaller doses (≤0.15 mL), a 30- or 50-unit syringe improves accuracy.
Administration
1. Route: Subcutaneous injection
2. Sites: Abdomen or thigh
3. Rotate injection sites regularly
4. Always use sterile syringes and proper disposal methods
Storage Method
| State | Storage |
|---|---|
| Unreconstituted powder | −20 °C (freezer), dry & dark |
| Reconstituted solution | 2–8 °C (refrigerator) |
| Shelf life (mixed) | Best used within 30 days |
| Avoid | Repeated freeze-thaw cycles |
Common Side Effects
Usually mild and temporary:
1. Nausea (most common)
2. Facial flushing
3. Headache
4. Temporary increase in blood pressure
Starting at a lower dose can help reduce side effects.
