Palopegteriparatide

Palopegteriparatide API

Palopegteriparatide is a long-acting parathyroid hormone receptor agonist (PTH1R agonist), developed for the treatment of chronic hypoparathyroidism. It is a pegylated analog of PTH (1-34) designed to provide sustained calcium regulation with once-weekly dosing.

Mechanism & Research:
Palopegteriparatide binds to PTH1 receptors, restoring calcium and phosphate balance by:

• Increasing serum calcium

• Decreasing urinary calcium excretion

• Supporting bone metabolism and mineral homeostasis