OEM Human Growth Hormone - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
OEM Human Growth Hormone - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:
Product Detail
| Name | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| CAS number | 14636-12-5 |
| Molecular formula | C52H74N16O15S2 |
| Molecular weight | 1227.37 |
| EINECS Number | 238-680-8 |
| Boiling point | 1824.0±65.0 °C (Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Storage conditions | Keep in dark place, Inert atmosphere, Store in freezer, under -15°C. |
| Acidity coefficient | (pKa) 9.90±0.15 (Predicted) |
Synonyms
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Description
Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.
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We enjoy a very good reputation among our customers for our excellent product quality, competitive price and the best service for OEM Human Growth Hormone - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: Qatar, Chile, Malta, We can meet the various needs of customers at home and abroad. We welcome new and old customers to come to consult & negotiate with us. Your satisfaction is our motivation! Allow us to work together to write a brilliant new chapter!
By Margaret from Grenada - 2017.07.28 15:46
Superb technology, perfect after-sales service and efficient work efficiency, we think this is our best choice.
By Florence from Norwegian - 2018.10.09 19:07
