CJC1295 without DAC is a synthetic peptide classified as a Growth Hormone Releasing Hormone (GHRH) analog. It is designed to stimulate the pituitary gland to release growth hormone (GH), which in turn increases levels of insulin-like growth factor 1 (IGF-1).

The term “without DAC” refers to the absence of Drug Affinity Complex (DAC) — a structural modification that significantly extends the peptide’s half-life. Without DAC, CJC1295 acts as a short-acting peptide, producing a more natural, pulsatile release of growth hormone.

1. Mechanism of Action

CJC1295 without DAC mimics endogenous GHRH. After administration, it binds to GHRH receptors in the anterior pituitary gland and stimulates the release of growth hormone.

Unlike direct GH injections, this peptide encourages the body to produce its own GH, maintaining physiological regulation.

Key characteristics:

• Promotes natural GH pulse patterns

• Short half-life (30 minutes)

• Lower risk of prolonged GH elevation

• Does not continuously overstimulate the pituitary

2. CJC1295 With DAC vs. Without DAC

The short-acting version is often preferred by individuals seeking a more natural hormonal rhythm.

3. Potential Benefits

Research discussions and anecdotal reports suggest possible effects including:

1. Increased Lean Muscle Mass

Elevated GH and IGF-1 support protein synthesis and muscle recovery.

2. Fat Reduction

Growth hormone enhances lipolysis (fat breakdown).

3. Improved Recovery

May reduce recovery time after intense training.

4. Enhanced Sleep Quality

GH is primarily released during deep sleep cycles.

5. Anti-aging Research Interest

Some studies explore its potential impact on skin elasticity and vitality.

4. Usage Guide (For Research & Educational Purposes Only)

⚠️ Important Disclaimer:
CJC1295 is generally sold as a research chemical and is not approved for medical use in many countries. The following information is for educational purposes only and does not constitute medical advice.

4.1 Common Form

• 2 mg or 5 mg lyophilized (freeze-dried) powder

• Requires reconstitution with bacteriostatic water

4.2 Reconstitution Instructions

Materials Needed:

• Vial of CJC1295 without DAC

• Bacteriostatic water

• Insulin syringe

• Alcohol swabs

Steps:

1. Disinfect the vial stopper with alcohol.

2. Slowly inject bacteriostatic water down the inside wall of the vial (avoid direct pressure on powder).

3. Gently swirl — do not shake.

4. Store refrigerated at 2–8°C (36–46°F).

4.3 Common Research Dosage Reference

(Not medical advice)

• 100–300 mcg per injection

• 1–3 times daily

Common timing:

• Morning (fasted)

• Post-workout

• Before sleep

Because of its short half-life, multiple daily administrations are often discussed.

4.4 Administration Method

• Subcutaneous injection

• Common site: abdominal fat area

• Rotate injection sites

• Use sterile technique

5. Common Research Combinations

In peptide research discussions, CJC1295 without DAC is often combined with:

• Ipamorelin

• GHRP-2

• GHRP-6

These compounds may amplify growth hormone release through complementary mechanisms.

6. Possible Side Effects

While generally considered well-tolerated in research settings, potential effects may include:

• Mild water retention

• Tingling in hands (similar to GH effects)

• Headache

• Injection site irritation

• Increased appetite (when combined with certain GHRPs)

Long-term safety data remains limited.

7. Suggested Research Cycle Length

• 8–12 weeks per cycle

• 2–4 weeks break recommended

• IGF-1 monitoring suggested

8. Storage Guidelines

• Refrigerate unopened vials

• Use within 20–30 days after reconstitution

• Avoid temperature fluctuations

9. Final Summary

CJC1295 without DAC is a short-acting GHRH analog designed to stimulate the body’s natural growth hormone production. Compared to the DAC-modified version, it more closely mimics physiological GH pulses but requires more frequent administration.

Although popular in research and performance communities, it remains a non-approved compound in many regions. Proper education, caution, and professional guidance are essential before considering its use.