Melanotan II

Melanotan II API 

Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), developed to stimulate melanogenesis, enhance UV protection, and modulate sexual and metabolic functions. It acts as a non-selective agonist of melanocortin receptors, particularly MC1R, MC3R, and MC4R.

Originally studied for its tanning and photoprotective properties, Melanotan II has also shown effects on libido enhancement, appetite suppression, and energy balance, making it a multifunctional research peptide with interest in dermatology, endocrinology, and sexual medicine.

Mechanism of Action

Melanotan II works by activating several melanocortin receptors:

• MC1R: Stimulates melanin production → increases skin pigmentation and UV protection

• MC3R / MC4R: Involved in appetite control, libido enhancement, and energy homeostasis

• Crosses the blood-brain barrier, influencing central neurohormonal pathways

Research and Potential Applications

Although not approved for medical use, Melanotan II is widely studied for the following:

1. Skin Pigmentation & UV Protection

• Promotes eumelanin synthesis, leading to natural tanning

• Provides photo-protective effects without sun exposure

• Potential for reducing skin cancer risk in fair-skinned individuals

2. Sexual Dysfunction

• Shown to increase libido and sexual arousal in both men and women

• Studied as a potential therapy for erectile dysfunction (ED) via MC4R activation

3. Appetite & Weight Management

• May reduce appetite and food intake by acting on hypothalamic pathways

• Potential adjunct in obesity research

API Features (by Gentolex Group)

• High purity ≥ 99% (HPLC & LC-MS confirmed)

• Synthesized via solid-phase peptide synthesis (SPPS)

• Low endotoxin, low residual solvents

• Available in R&D to commercial scale