Ipamorelin

Ipamorelin API 

Ipamorelin is a synthetic pentapeptide growth hormone releasing peptide (GHRP) composed of five amino acids (Aib-His-D-2-Nal-D-Phe-Lys-NH₂). It is a selective GHSR-1a agonist with the ability to stimulate growth hormone (GH) secretion with high specificity. Compared with earlier GHRPs (such as GHRP-2 and GHRP-6), Ipamorelin shows better selectivity, safety and pharmacological stability without significantly affecting the levels of other hormones such as cortisol, prolactin or ACTH.

As a highly-regarded peptide API, Ipamorelin is currently widely used in anti-aging research, sports rehabilitation, osteoporosis intervention, postoperative recovery and metabolic function regulation.

Research and Mechanism of Action

Ipamorelin promotes the release of endogenous growth hormone (GH) from the anterior pituitary by selectively activating the growth hormone secretion receptor (GHSR-1a) and mimicking the action of ghrelin. Its main pharmacological mechanisms include:
1. Stimulate GH secretion
Ipamorelin highly selectively excites GHSR-1a, prompting the pituitary gland to release GH without significantly affecting ACTH or cortisol levels, and has better endocrine safety.
2. Enhance protein synthesis and cell repair
By increasing IGF-1 levels, it promotes muscle cell anabolism, enhances tissue repair and regeneration, and is suitable for trauma repair, surgical recovery and anti-muscle atrophy treatment.
3. Improve metabolism and fat distribution
GH has the effects of fat mobilization and insulin sensitivity improvement. Ipamorelin can assist in regulating metabolic status and is used in research on metabolic syndrome and obesity intervention.
4. Improve bone density and anti-aging
GH/IGF-1 axis can promote bone formation and mineralization. Ipamorelin shows promise in anti-osteoporosis, fracture rehabilitation and anti-aging.
5. Improve circadian rhythm and sleep quality
GH release is usually accompanied by deep sleep. Studies have found that Ipamorelin can indirectly improve sleep structure and improve physiological recovery ability.
Preclinical studies and efficacy verification

Although still in the preclinical/early clinical stage, Ipamorelin has shown good safety and efficacy in animal and some human studies:

GH levels are significantly increased (peak within 30 minutes, lasting for several hours)

No obvious pro-cortisol or pro-ACTH effect, endocrine effects are more controllable

Improve muscle mass and strength (especially in elderly animal models)

Improve postoperative recovery and tissue repair speed

Increased IGF-1 levels help cell repair and antioxidant response

In addition, Ipamorelin combined with other GHRH mimetics (such as CJC-1295) in some studies showed synergistic effects, further enhancing the pulse release of GH.
API production and quality assurance

The Ipamorelin API provided by our Gentolex Group is prepared using high-standard **solid phase peptide synthesis process (SPPS)**, and is strictly purified and quality tested, suitable for scientific research and development and early pipeline use of pharmaceutical companies.

Product features include:

Purity ≥99% (HPLC test)
No endotoxin, low residual solvent, low metal ion contamination
Provide a full set of quality documents: COA, stability study report, impurity spectrum analysis, etc.
Customizable gram-level~kilogram-level supply