High Performance Impurities Of Amino Acids - Vancomycin is a glycopeptide antibiotic used for antibacterial – Gentolex

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High Performance Impurities Of Amino Acids - Vancomycin is a glycopeptide antibiotic used for antibacterial – Gentolex Detail:

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Name	Vancomycin
CAS number	1404-90-6
Molecular formula	C66H75Cl2N9O24
Molecular weight	1449.25
EINECS Number	215-772-6
Density	1.2882 (rough estimate)
Refractive index	1.7350 (estimate)
Storage conditions	Sealed in dry, 2-8°C

Synonyms

Vancomycin(baseand/orunspecifiedsalts);VANCOMYCIN;VancomycinBase;(3S,6R,7R,22R,23S,26S,36R,38aR)-3-(2-Amino-2-oxoethyl)-44-[[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-α-L-lyxo-hexopyranosyl)-β-D-glucopyranosyl]oxy]-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-[[(2R)-4-methChemicalbookyl-2-(methylamino)-1-oxopentyl]amino]-2,5,24,38,39-pentaoxo-22H-8,11:18,21-Dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylicacid.

Description

Vancomycin is a glycopeptide antibiotic. Its mechanism of action is to bind with high affinity to the alanylalanine at the poly-terminal end of the precursor peptide of the sensitive bacterial cell wall, blocking the synthesis of the macromolecular peptidoglycan that constitutes the bacterial cell wall, resulting in Destruction of the cell wall kills bacteria. Vancomycin is effective for serious infections caused by Gram-positive bacteria, especially those caused by methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, and Enterococcus that are resistant to other antibiotics or have poor efficacy.

Indications

It is limited to systemic infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and intestinal infections and systemic infections caused by Clostridium difficile; penicillin-allergic patients cannot use penicillins or cephalosporins in patients with severe staphylococcal infection, or those with severe staphylococcal infection who have failed to respond to the above antibiotics, vancomycin can be used. This product is also used for the treatment of Enterococcus endocarditis and Corynebacterium (Diphtheria-like) endocarditis in people allergic to penicillin. Treatment of staphylococcus-induced arteriovenous shunt infections in hemodialysis patients allergic to penicillin and non-allergic to penicillin.

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