Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH

Research Application:
This compound is a modified lysine derivative used in peptide synthesis, particularly for constructing targeted or multifunctional peptide conjugates. The Fmoc group allows for stepwise synthesis via Fmoc solid-phase peptide synthesis (SPPS). The side chain is modified with a stearic acid derivative (Ste), γ-glutamic acid (γ-Glu), and two AEEA (aminoethoxyethoxyacetate) linkers, which provide hydrophobicity, charge properties, and flexible spacing. It is commonly studied for its role in drug delivery systems, including antibody-drug conjugates (ADCs) and cell-penetrating peptides.

Function:
Fmoc-L-Lys[Ste(OtBu)-γ-Glu(OtBu)-AEEA-AEEA]-OH functions as a building block for developing long-chain lipidated peptides or drug-linker complexes. The stearic acid enhances membrane affinity, γ-Glu improves stability and enzymatic resistance, and AEEA linkers provide solubility and structural flexibility. Together, these features make the compound valuable in designing peptides for improved bioavailability, controlled release, and targeted delivery applications.