Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH

Research Application:
This compound is a protected, functionalized lysine derivative used in peptide synthesis and drug conjugate development. It features an Fmoc group for N-terminal protection, and a side-chain modification with Eic(OtBu) (eicosanoic acid derivative), γ-glutamic acid (γ-Glu), and AEEA (aminoethoxyethoxyacetate). These components are designed to study lipidation effects, spacer chemistry, and controlled drug release. It is widely researched in the context of prodrug strategies, ADC linkers, and membrane-interacting peptides.

Function:
Fmoc-L-Lys[Eic(OtBu)-γ-Glu(OtBu)-AEEA]-OH serves as a building block for synthesizing lipid-modified peptides or drug delivery systems. The Eic moiety improves lipophilicity and membrane binding; γ-Glu adds enzymatic stability and targeting potential; and AEEA acts as a flexible hydrophilic linker. Together, they enable the construction of peptides with enhanced cellular uptake, extended half-life, and site-specific delivery properties.