Fmoc-Gly-Gly-OH

Fmoc-Gly-Gly-OH

Research Application:
Fmoc-Gly-Gly-OH is a dipeptide used as a basic building block in solid-phase peptide synthesis (SPPS). It features two glycine residues and an Fmoc-protected N-terminus, allowing for controlled peptide chain elongation. Due to glycine’s small size and flexibility, this dipeptide is often studied in the context of peptide backbone dynamics, linker design, and structural modeling in peptides and proteins.

Function:
Fmoc-Gly-Gly-OH provides a flexible and uncharged segment within a peptide sequence. Glycine residues introduce conformational freedom, making this dipeptide ideal for linkers, turns, or unstructured regions in functional peptides. It is widely used in the design of bioactive peptides, enzyme substrates, and bioconjugates where minimal steric hindrance and flexibility are desired.