BPC-157 5mg

BPC-157 Peptide

BPC-157, also known as Pentadecapeptide BPC-157 or Body Protection Compound-157, is a synthetically produced bioactive peptide. Multiple studies suggest that it may play a role in the healing and regeneration of joints, tendons, muscle tissue, and neural tissue.

BPC-157 is composed of 15 amino acids and was originally identified as a stable peptide fragment isolated from gastric juice. Due to its amino acid length, it is commonly referred to as a pentadecapeptide.

BPC-157 has attracted significant research interest for its potential role in wound healing and tissue repair. Studies indicate that BPC-157 may interact with or stimulate growth hormone (GH) receptors, thereby inducing GH-like biological effects and promoting cellular proliferation.

This activity may contribute to:

        1. Collagen synthesis

        2. Formation of new tissue

        3. Angiogenesis (the development of new blood vessels)

Angiogenesis is a critical component of tissue repair, as it improves oxygen and nutrient delivery to damaged areas, potentially accelerating the reconstruction and healing process.

Serotonin (5-HT) is a key neurotransmitter within the gastrointestinal system and is abundantly present in the gastrointestinal tract and mucosa. Alterations in serotonin levels may influence gastric acid secretion, mucosal barrier integrity, and gastric blood flow.

Research suggests that BPC-157 may exhibit regulatory effects on serotonin-mediated pathways, including:

       1. Potential antagonism of 5-HT2A receptors

       2. Limitation of serotonin binding to these receptors

       3. Reduction of serotonin-induced physiological effects

As a result, BPC-157 has been studied for its potential role in gastrointestinal function modulation.

Current studies have explored BPC-157 in relation to:

       1. Tissue and wound repair

       2. Inflammatory response modulation

       3. Pain perception mechanisms

       4. Gastrointestinal function regulation

       5. Repair of tendons, ligaments, muscle tissue, and bone cells

Experimental findings suggest that its mechanisms may involve enhancement of functional recovery, promotion of angiogenesis, and anti-inflammatory activity.

       1. Molecular Formula: C₆₂H₉₈N₁₆O₂₂

       2. Molecular Weight: 1419.55 g/mol

       3. Alternative Name: Body Protection Compound-157 (BPC-157)

BPC-157 and Wound Healing

In multiple animal experimental models—including skin injury models, colonic anastomosis models, and synthetic sponge implantation models—researchers observed:

        1. Increased collagen content

        2. Enhanced reticular fiber formation

        3. Significantly elevated angiogenesis

Compared with control groups, BPC-157-treated models demonstrated improved structural tissue reconstruction.

Cellular and Molecular Mechanisms

Further studies indicate that BPC-157 may:

       1. Increase expression of vascular endothelial growth factor (VEGF)

       2. Promote proliferation and migration of endothelial cells such as HUVECs

       3. Accelerate formation of vascular-like structures under in-vitro conditions

Additionally, BPC-157 may influence intracellular signaling pathways, including:

       1. Regulation of ERK1/2 phosphorylation

       2. Downstream transcription factors such as c-Fos and c-Jun

These signaling cascades are essential for cell proliferation, migration, and tissue regeneration.