China OEM Sebacic Acid Di-N-Octyl Ester 2432-87-3 - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
China OEM Sebacic Acid Di-N-Octyl Ester 2432-87-3 - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:
Product Detail
| Name | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| CAS number | 14636-12-5 |
| Molecular formula | C52H74N16O15S2 |
| Molecular weight | 1227.37 |
| EINECS Number | 238-680-8 |
| Boiling point | 1824.0±65.0 °C (Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Storage conditions | Keep in dark place, Inert atmosphere, Store in freezer, under -15°C. |
| Acidity coefficient | (pKa) 9.90±0.15 (Predicted) |
Synonyms
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Description
Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.
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Innovation, good quality and reliability are the core values of our enterprise. These principles today extra than ever form the basis of our success as an internationally active mid-size organization for China OEM Sebacic Acid Di-N-Octyl Ester 2432-87-3 - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: California, Puerto Rico, Seattle, We aspire to meet the demands of our customers globally. Our range of merchandise and services is continuously expanding to meet customers' requirements. We welcome new and old customers from all walks of life to contact us for future business relationships and achieving mutual success!
By Arlene from Estonia - 2018.12.25 12:43
This supplier offers high quality but low price products, it is really a nice manufacturer and business partner.
By tobin from Philippines - 2017.11.01 17:04
