Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Short Description:

Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH is a protected tetrapeptide used in peptide synthesis and structural studies. The Boc (tert-butyloxycarbonyl) group protects the N-terminus, while Trt (trityl) groups protect the side chains of histidine and glutamine to prevent unwanted reactions. The presence of Aib (α-aminoisobutyric acid) promotes helical conformations and enhances peptide stability. This peptide is valuable for investigating peptide folding, stability, and as a scaffold for designing biologically active peptides.

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Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Research Application:
This protected tetrapeptide is used in peptide synthesis and conformational studies. The incorporation of Aib (α-aminoisobutyric acid) allows researchers to investigate helical structures and folding behavior in short peptides. The protected functional groups (Boc, Trt) ensure stability and selectivity during solid-phase peptide synthesis, making it a valuable model for studying peptide backbone dynamics and side-chain interactions.

Function:
Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH serves as a model compound for exploring peptide stability and structural motifs. Aib contributes to helical stabilization, while histidine and glutamine residues provide potential interaction sites, useful in designing bioactive peptides or mimicking protein fragments. It can also be a precursor for functional peptides in drug development or biochemical assays.

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