Big discounting Common Amino Acids - Ganirelix Acetate Peptide API – Gentolex

Short Description:

Send email to us

Product Detail

Product Tags

Feedback (2)

We emphasize progress and introduce new merchandise into the market each and every year for Natrium Thioglycolate, Glatiramer, Boc-Cefcapene.Dipa, We are willing to give you the best suggestions on the designs of your orders in a professional way if you need. In the meantime, we keep on developing new technologies and creating new designs so as to make you ahead in the line of this business.

Big discounting Common Amino Acids - Ganirelix Acetate Peptide API – Gentolex Detail:

Product Detail

Name	Ganirelix Acetate
CAS number	123246-29-7
Molecular formula	C80H113ClN18O13
Molecular weight	1570.34

Synonyms

Ac-DNal-DCpa-DPal-Ser-Tyr-DHar(Et2)-Leu-Har(Et2)-Pro-DAla -NH2;Ganirelixum;ganirelix Acetate; GANIRELIX; Ganirelix Acetate USP/EP/

Description

Ganirelix is a synthetic decapeptide compound, and its acetate salt, Ganirelix acetate is a gonadotropin-releasing hormone (GnRH) receptor antagonist. The amino acid sequence is: Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-Tyr-D-HomoArg(9,10-Et2)-Leu-L-HomoArg(9,10-Et2)-Pro-D- Ala-NH2. Mainly clinically, it is used in women undergoing assisted reproductive technology controlled ovarian stimulation programs to prevent premature luteinizing hormone peaks and to treat fertility disorders due to this cause. The drug has the characteristics of less adverse reactions, high pregnancy rate and short treatment period, and has obvious advantages compared with similar drugs in clinical practice.

Pharmacological Action

The pulsatile release of gonadotropin-releasing hormone (GnRH) stimulates the synthesis and secretion of LH and FSH. The frequency of LH pulses in the mid and late follicular phases is approximately 1 per hour. These pulses are reflected in transient rises in serum LH. During mid-menstrual period, the massive release of GnRH causes a surge of LH. The midmenstrual LH surge can trigger several physiological responses, including: ovulation, oocyte meiotic resumption, and corpus luteum formation. The formation of the corpus luteum causes serum progesterone levels to rise, while estradiol levels fall. Ganirelix acetate is a GnRH antagonist that competitively blocks GnRH receptors on pituitary gonadotrophs and subsequent transduction pathways. It produces a rapid, reversible inhibition of gonadotropin secretion. The inhibitory effect of ganirelix acetate on pituitary LH secretion was stronger than that on FSH. Ganirelix acetate failed to induce the first release of endogenous gonadotropins, consistent with antagonism. Complete recovery of pituitary LH and FSH levels occurred within 48 hours after ganirelix acetate was discontinued.

Product detail pictures:

Related Product Guide:

With our excellent administration, strong technical capability and strict excellent control method, we carry on to offer our clients with responsible good quality, reasonable costs and great companies. We intention at becoming considered one of your most responsible partners and earning your pleasure for Big discounting Common Amino Acids - Ganirelix Acetate Peptide API – Gentolex , The product will supply to all over the world, such as: Yemen, Belarus, Hyderabad, Our solutions have national accreditation requirements for qualified, good quality products, affordable value, was welcomed by individuals all over the world. Our products will continue to improve inside the order and appear forward to cooperation with you, Definitely should any of those goods be of curiosity to you, be sure to letus know. We'll be satisfied to supply you a quotation up on receipt of the detailed needs.

2-Ethoxy-1-Naphthoicacid