Big discounting 2,2-Dimethyl-5-(3-Thienyl)-1,3-Dioxane-4,6-Dione - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex
Big discounting 2,2-Dimethyl-5-(3-Thienyl)-1,3-Dioxane-4,6-Dione - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex Detail:
Product Detail
| Name | N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin |
| CAS number | 14636-12-5 |
| Molecular formula | C52H74N16O15S2 |
| Molecular weight | 1227.37 |
| EINECS Number | 238-680-8 |
| Boiling point | 1824.0±65.0 °C (Predicted) |
| Density | 1.46±0.1 g/cm3(Predicted) |
| Storage conditions | Keep in dark place, Inert atmosphere, Store in freezer, under -15°C. |
| Acidity coefficient | (pKa) 9.90±0.15 (Predicted) |
Synonyms
[N-α-Triglycyl-8-lysine]-vasopressin;130:PN: WO2010033207SEQID:171claiMedprotein; 1-Triglycyl-8-lysineVasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Terlipressin, Terlipressine, Terlipressina, Terlipressinum.
Description
Terlipressin, whose chemical name is triglycyllysine vasopressin, is a new synthetic long-acting vasopressin preparation. It is a kind of prodrug, which is inactive by itself. It is acted by aminopeptidase in vivo to slowly “release” the active lysine vasopressin after removing the three glycyl residues at its N-terminus. Therefore, terlipressin acts as a reservoir that releases lysine vasopressin at a steady rate.
The pharmacological effect of terlipressin is to contract splanchnic vascular smooth muscle and reduce splanchnic blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal blood flow and portal pressure. On the other hand, it can also reduce plasma The effect of renin concentration, thereby increasing renal blood flow, improving renal function and increasing urine output in patients with hepatorenal syndrome. Terlipressin is currently the only drug that can improve the survival rate of patients with esophageal variceal hemorrhage. It was mainly used in the clinical treatment of variceal hemorrhage. In addition, terlipressin has also been successfully used in the liver and kidney. In general, it is likely to play a beneficial role in coexisting refractory shock and cardiopulmonary resuscitation. Compared with vasopressin, it has a long-lasting effect, does not cause dangerous complications, including fibrinolysis and serious complications in the cardiovascular system, and is simple to use (intravenous injection), which is more suitable for acute and critical care. Rescue and treatment of critically ill patients.
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Having a positive and progressive attitude to customer's fascination, our organization constantly improves our solution high-quality to fulfill the requirements of shoppers and further focuses on safety, reliability, environmental prerequisites, and innovation of Big discounting 2,2-Dimethyl-5-(3-Thienyl)-1,3-Dioxane-4,6-Dione - Terlipressin Acetate for Esophageal Variceal Bleeding – Gentolex , The product will supply to all over the world, such as: Nepal, Ethiopia, Uruguay, We follow superior mechanism to process these goods that ensure optimum durability and reliability of the goods. We follow latest effective washing and straightening processes that enable us to supply unmatched quality of items for our clients. We continually strive for perfection and all our efforts are directed towards attaining complete client satisfaction.
By Anne from San Francisco - 2017.01.28 18:53
This is a very professional wholesaler, we always come to their company for procurement, good quality and cheap.
By Kevin Ellyson from Sri Lanka - 2018.11.04 10:32
