Best Price on Diisopropylamine Dichloroacetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex
Best Price on Diisopropylamine Dichloroacetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex Detail:
Product Detail
| Name | CARBETOCIN |
| CAS number | 37025-55-1 |
| Molecular formula | C45H69N11O12S |
| Molecular weight | 988.17 |
| EINECS Number | 253-312-6 |
| Specific rotation | D -69.0° (c = 0.25 in 1M acetic acid) |
| Boiling point | 1477.9±65.0 °C (Predicted) |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Storage conditions | -15°C |
| Form | powder |
Synonyms
BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2, (SULFIDEBONDBETWEENBUTYRYL-4-YLANDCYS); BUTYRYL-TYR(ME)-ILE-GLN-ASN-CYS-PRO-LEU-GLY-NH2TRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-1-CARBAOXYTOC INTRIFLUOROACETATESALT; (BUTYRYL1, TYR(ME)2)-OXYTOCIN; (BUTYRYL1,TYR(ME)2)-OXYTOCINTRIFLUOROACETATESALT; CARBETOCIN; CARBETOCINTRIFLUOROACETATESALT; (2-O-METHYLTYROSINE)-DE-AMINO-1-CARBAOXYTOCIN
Biological activity
Carbetocin, an oxytocin (OT) analog, is an oxytocin receptor agonist with a Ki of 7.1 nM. Carbetocin has a high affinity (Ki=1.17 μM) for the chimeric N-terminus of the oxytocin receptor. Carbetocin has potential for postpartum hemorrhage research. Carbetocin can penetrate the blood-brain barrier and has antidepressant-like activity by activating oxytocin receptors in the CNS.
Function
Carbetocin is a synthetic long-acting oxytocin 8-peptide analog with agonist properties, and its clinical and pharmacological properties are similar to those of naturally occurring oxytocin. Like oxytocin, carbetocin binds to the hormone receptors of uterine smooth muscle, causing rhythmic contractions of the uterus, increasing its frequency and increasing uterine tone on the basis of the contractions of the original. Oxytocin receptor levels in the uterus are low in the non-pregnant state, increase during pregnancy, and peak during labor. Therefore, carbetocin has no effect on the non-pregnant uterus, but has a potent uterine contractile effect on the pregnant uterus and the newly produced uterus.
Change Controls
Changes are controlled according to the procedure. Based on the impact and risk and severity, changes are classified as Major, Minor and Site. Site changes have slight impact on safety and quality of product, and therefore do not need approval and notification to the customer; Minor changes have moderate impact on safety and quality of product, and need to notify the customer; Major changes have higher impact on safety and quality of product, and need approval by the customer.
According to the procedure, change control is started with change application in which change details and rational for the change are described. The evaluation is then performed following the application, which is done by change control relevant departments. Meanwhile, the change control is classified into Major level, General level and Minor level. After appropriate evaluation as well as the classification, all level change control should be approved by QA Manager. The change control is executed after approval according to the action plan. The change control is finally closed after QA confirms the change control has been appropriately implemented. If involving client notification, the client should be notified timely after change control approved
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"Sincerity, Innovation, Rigorousness, and Efficiency" is definitely the persistent conception of our corporation to the long-term to establish alongside one another with customers for mutual reciprocity and mutual profit for Best Price on Diisopropylamine Dichloroacetate - Carbetocin to Prevent Uterine Contraction and Postpartum Hemorrhage – Gentolex , The product will supply to all over the world, such as: French, United Arab emirates, luzern, As a way to use the resource on the expanding info in international trade, we welcome prospects from everywhere on the web and offline. In spite on the high quality objects we offer you, effective and satisfying consultation service is supplied by our qualified after-sale service group. Item lists and in depth parameters and any other info weil be sent to you timely for the inquiries. So you should make contact with us by sending us emails or call us when you've got any questions about our organization. ou could also get our address information from our site and come to our enterprise. We get a field survey of our merchandise. We're confident that we are going to share mutual accomplishment and create solid co-operation relations with our companions within this market place. We're seeking forward for your inquiries.
By Sarah from Turin - 2017.10.23 10:29
The product manager is a very hot and professional person, we have a pleasant conversation, and finally we reached a consensus agreement.
By mary rash from Istanbul - 2017.06.25 12:48
