AEEA-AEEA

AEEA-AEEA (Aminoethoxyethoxyacetate dimer)

Research Application:
AEEA-AEEA is a hydrophilic, flexible spacer commonly used in peptide and drug conjugation research. It consists of two ethylene glycol-based units, making it useful for studying the effects of linker length and flexibility on molecular interactions, solubility, and biological activity. Researchers often use AEEA units to evaluate how spacers influence the performance of antibody-drug conjugates (ADCs), peptide-drug conjugates, and other bioconjugates.

Function:
AEEA-AEEA functions as a biocompatible linker that enhances solubility, reduces steric hindrance, and improves molecular flexibility. It helps separate functional domains within a molecule, such as targeting ligands and payloads, allowing for more efficient binding and activity. Its non-immunogenic and hydrophilic nature also contributes to improved pharmacokinetic profiles in therapeutic applications.